General Details

The HPE ProLiant ML350 Gen12 is a powerful 2-socket tower server (also rack-convertible) engineered for growing businesses, remote offices and branch datacenters that require high performance, flexibility and enterprise-grade security.
Powered by up to two Intel® Xeon® 6700P/6500P-series processors (up to 86 P-cores per socket) and supporting up to 8 TB of DDR5 memory, the ML350 Gen12 handles demanding workloads including virtualization, VDI, data analytics and ERP/CRM with ease.
Delivers flexible storage configurations (LFF, SFF, NVMe, EDSFF) and high-speed I/O expansion (PCIe Gen5, OCP 3.0) so it can grow as your infrastructure needs evolve.
Built-for-security from the silicon up, with HPE’s Immutable Silicon Root of Trust, TPM 2.0, UEFI Secure Boot, intrusion detection and optional lockable bezels — helping safeguard your infrastructure lifecycle.

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HPE ProLiant ML350 Gen12 Key Features

Key Features

Scalable 2-socket performance

Supports dual Intel® Xeon® 6700/6500 P-series processors (8 to 86 P-cores each) for multi-threaded compute, virtualization or branch datacenter workloads.

Memory capacity up to 8 TB (with DDR5 Smart Memory), enabling large in-memory databases, VDI user density and analytics workloads.

Flexible storage & I/O

Choose from LFF (Large Form Factor) SAS/SATA, SFF (Small Form Factor), NVMe or EDSFF drive cages — up to 12 LFF / 24 SFF / 12 EDSFF depending on model.

Expansion includes up to 10 PCIe Gen5 slots plus 2 OCP slots for networking or accelerators — ready for future-proof architectures.

Enterprise-grade security & management

Includes HPE iLO (Integrated Lights-Out) Standard with Intelligent Provisioning, supporting full lifecycle management, remote control and monitoring.

Security features like Immutable Silicon Root of Trust, UEFI Secure Boot, TPM 2.0, padlock slot and front key-lock bezel ensure the server remains secure from factory to decommission.

HPE ProLiant ML350 Gen12 Specifications

Processor Intel® Xeon® 6700/6500 P-series (P-cores) processors; 1 or 2 sockets; 8 to 86 P-cores per processor; up to 3.5 GHz max depending on SKU.

Memory Up to 8.0 TB using HPE DDR5 Smart Memory; 32 DIMM slots (in dual-socket config) for advanced ECC, online spare, memory lock-step modes.

Storage Supported Drive options vary: Up to 12 LFF SAS/SATA, or up to 24 SFF SAS/SATA/NVMe, or up to 12 EDSFF NVMe SSDs — depending on chosen model.

Expansion / Slots Up to 10 PCIe Gen5 slots plus 2 OCP slots (for network/accelerator) in select builds.

Security & Management HPE iLO Standard (embedded), Intelligent Provisioning, TPM 2.0, UEFI Secure Boot, Immutable Silicon Root of Trust, padlock slot/security bezel.

HPE ProLiant ML350 Gen12 Documents

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HPE ProLiant ML350 Gen12 Tower Server

The HPE ProLiant ML350 Gen12 is HPE’s high-end dual-socket tower server built for scalability, performance and enterprise-grade security. With support for the latest Intel Xeon 6700/6500 P-series processors (up to 86 P-cores per socket), and up to 8 TB of DDR5 Smart Memory, it’s well suited for virtualization, VDI, data-intensive workloads, remote offices or branch datacenters.

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HPE ProLiant ML350 Gen12 Key Features

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